The Onion's AV Club has a Q&A this week with "Family Guy" creator Seth MacFarlane. Some interesting factoids: Did you know that the staff of "The Simpsons" hates "The Family Guy"? Or that Willam H. Macy tried out for the part of Stewie? (MacFarlane himself ended up getting the role.)
And apparently the "Family Guy" DVD commentaries were heavily edited, due to MacFarlane's vindictive tangents and the consumption of alcohol while they were recorded.